Click here for a complete and updated list of publications on PubMed

Li T, Stark MR, Johnson AD and Wolberger C (1995) “Crystal structure of the MAT a1/MAT α2 homeodomain heterodimer bound to DNA,” Science 270, 262-269 [PubMed]
Soisson S, MacDougall-Shackleton B, Schleif R, and Wolberger C (1997) “Structural basis for ligand-regulated oligomerization of AraC,” Science 276, 421-425 [PubMed]
Soisson S, MacDougall-Shackleton B, Schleif R, and Wolberger C (1997) “The 1.6 Å crystal structure of the AraC sugar-binding and dimerization domain complexed with D-fucose: Structural basis for carbohydrate specificity,” J. Mol. Biol. 273, 226-237 [PubMed]
Batchelor A, Piper D, Charles de la Brousse F, McKnight SL and Wolberger C (1998), “The structure of GABPα/Β: An ETS domain – ankyrin repeat heterodimer bound to DNA,” Science 279, 1037-1041 [PubMed]
Piper D, Batchelor A, Cleary M and Wolberger C (1999), “Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in combinatorial interactions,” Cell 96, 587-597 [PubMed]
Wolberger C (1999) “Multiprotein-DNA Complexes in Transcriptional Regulation,” Annu. Rev. Biophys. Biomol. Struct. 28, 29-56 [PubMed]
Jabet C, Gitti R, Summers M and Wolberger C (1999), “NMR studies of the Pbx1 TALE homeodomain protein free in solution and bound to DNA: Proposal for a mechanism of HoxB1-Pbx1-DNA complex assembly,” J. Mol. Biol. 291, 521-530 [PubMed]
Sprague ER, Redd M, Johnson AD and Wolberger C (2000), “Structure of the C-terminal domain of Tup1, a corepresser of transcription in yeast,” EMBO J.19,3016 – 3027 [PubMed]
VanDemark AP, Hofmann RM, Tsui C, Pickart CM and Wolberger C (2001) “Molecular Insights into Polyubiquitin Chain Assembly. Crystal Structure of the Mms2/Ubc13 Heterodimer,” Cell 105,711-720. [PubMed]
Garvie C, Hagman J and Wolberger C (2001) ” Structural studies of Ets-1/Pax5 complex formation on DNA,” Molecular Cell 8, 937-946 [PubMed]
Muller CW and Wolberger C (2002) “Protein–nucleic acid interactions.” Curr Opin Struct Biol. 12, 69-71.
Avalos J, Celic I, Muhammad S, Cosgrove M, Boeke J and Wolberger C (2002) “Structure of a Sir2 enzyme bound to an acetylated p53 peptide,” Molecular Cell 10, 523-535 [PubMed]
Garvie C, Pufall M, Graves BJ and Wolberger C (2002), “Structural analysis of the autoinhibition of Ets-1 and its role in protein parnership,” Journal of Biological Chemistry 277, 45529-45536 [PubMed]
Aishima J, Gitti RK, Noah J, Gan HH, Schlick T and Wolberger C (2002), ” A Hoogsteen base pair embedded in undistorted B-DNA,” Nucleic Acids Research 30, 5244-5252 [PubMed]
Ke A and Wolberger C (2003), “Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera,” Protein Science 12, 306-312 [PubMed]
LaRonde-LeBlanc N and Wolberger C (2003), “Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior,” Genes Dev. 17, 2060-2072 [PubMed]
Wu PU, Hanlon H, Eddins M, Tsui C, Rogers RS, Jensen JP, Matunis MJ, Weissman AM, Wolberger C and Pickart CM (2003) “A conserved catalytic residue in the ubiquitin-conjugating enzyme family,” EMBO J. 22, 5241-5250. [PubMed]
Avalos JL, Boeke J and Wolberger C (2004) “Structural Basis for the Mechanism and Regulation of Sir2 Enzymes,” Molecular Cell 12, 639 – 648. [PubMed]
Cosgrove MS, Boeke JD and Wolberger C (2004) “Regulated Nucleosome Mobility and the Histone Code,” Nature Structural and Molecular Biology 11, 1037-1043 [PubMed]
Avalos JL, Bever KM and Wolberger C (2005) Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Molecular Cell 17, 855-68. [PubMed]
Sauvé AA, Wolberger C, Schramm VL, and Boeke JD (2006) “The biochemistry of sirtuins,” Annual Reviews of Biochemistry 75, 435-465 [PubMed]
Cosgrove MS, Bever K, Avalos JL, Muhammad S, Zhang X and Wolberger C (2006), “The structural basis of sirtuin substrate affinity,” Biochemistry 45, 7511-21. [PubMed]
Wang T, Zhang X, Bheda P, Revollo JR, Imai S and Wolberger C (2006), “Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme,” Nature Structural and Molecular Biology 13, 661-662 [PubMed]
Hoff KG, Avalos JL, Sens K and Wolberger C (2006), “Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide,” Structure 14, 1231-1240 [PubMed]
Eddins MJ, Carlile CM, Gomez KM, Pickart CM and Wolberger C (2006), “Mms2/Ubc13 covalently bound to ubiquitin: structural basis of linkage-specific polyubiquitin chain formation,” Nature Structural and Molecular Biology 13, 915-920 [PubMed]
Eddins MJ, Varadan R, Fushman D, Pickart CM and Wolberger C (2007), “Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH,” J. Mol. Biol. 367, 204-211 [PubMed]
Feeser E and Wolberger C (2008), “Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants,” J. Mol. Biol. 380, 520-531 [PubMed]
Hawse WF, Hoff KG, Fatkins D, Daines A, Zubkova OV, Schramm VL, Zheng W and Wolberger C (2008), “Structural Insights Into Intermediate Steps in the Sir2 Deacetylation Reaction,” Structure 16, 1368-1377. [PubMed]
Wang T, Yin L, Cooper EM, Lai MY, Dickey S, Pickart CM, Fushman D, Wilkinson KD, Cohen RE and Wolberger C(2009), “Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1,” J. Mol. Biol. 386, 1011-1023. [PubMed]
Datta AB, Hura G and Wolberger C (2009) “The Structure and Conformation of Lys63-Linked Tetraubiquitin,” J. Mol. Biol. 392, 1117-1125. [PubMed]
Fahie K, Hu P, Swatkoski S, Cotter RJ, Zhang Y and Wolberger C (2009) “Side-chain specificity of ADP ribosylation by a sirtuin,” FEBS J. 276, 7159-76 [PubMed]
Hawse W.L. and Wolberger C (2009) “Structure-based mechanism of ADP ribosylation by sirtuins,” J. Biol. Chem. 284, 33654-33661. [PubMed]
Samara NL, Datta AB, Berndsen CE, Zhang X, Yao T, Cohen RE and Wolberger C (2010) “Structural insights into the assembly and function of the SAGA deubiquitinating module,” Science 328, 1025-1029. [PubMed]
Bheda P, Wang JT, Escalante-Semerena JC and Wolberger C (2011) “Structure of Sir2Tm bound to a propionylated peptide,” Protein Sci. 20, 131-9. [PubMed]
Samara NL and Wolberger C (2011) “A new chapter in the transcription SAGA,”Curr Opin Struct Biol. 2011 Dec;21(6):767-74. Epub 2011 Oct 18. [PubMed]
Berndsen CE and Wolberger C (2011) “A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins,” Anal Biochem. 418, 102-10. [PubMed]
Wiener R, Zhang X, Wang T and Wolberger C (2012) “The mechanism of OTUB1-mediated inhibition of ubiquitination,” Nature. 483(7391):618-22.[PubMed]
Bheda P, Swatkoski S, Fiedler KL, Boeke JD, Cotter RJ and Wolberger C (2012) “Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2,” Proc Natl Acad Sci U S A. 109(16):E916-25. [PubMed]
Samara NL, Ringel AE and Wolberger C (2012) “A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity,” Structure 20(8):1414-24. [PubMed]
Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C and Matunis MJ. (2012) “RNF4-Dependent hybrid SUMO-Ubiquitin chains aAre signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA Damage,” Sci Signal. Dec 4;5(253):ra88. [PubMed]
Berndsen CE, Wiener R, Yu IW, Ringel AE and Wolberger C (2013) “A conserved asparagine has a structural role in ubiquitin-conjugating enzymes,” Nat Chem Biol. Mar;9(3):154-6. [PubMed]
Wiener R, DiBello AT, Lombardi PM, Guzzo CM, Zhang X, Maunis MJ and Wolberger C (2013) “E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1,”. Nature Structural and Molecular Biology 20(9):1033-9. [PubMed]
Ringel AE, Wolberger C(2013) New RING tossed into an OLD HAT. Structure 21(9):1479-81. [PubMed]
Wolberger C(2014) Mechanisms for regulating deubiquitinating enzymes. Protein Science 3(4):344-53. [PubMed]
Berndsen CE and Wolberger C (2014) New insgights into ubiquitin E3 ligase mechanism. Nature Structural Biology21(4):301-7. [PubMed]
Cieniewicz AM, Moreland L, Ringel AE, Mackintosh SG, Raman A, Gilbert TM, Wolberger C, Tackett AJ, Taverna SD. The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3. Mol Cell Proteomics. 2014 Nov;13(11):2896-910. [PubMed]
Guzzo CM, Ringel A, Cox E, Uzoma I, Zhu H, Blackshaw S, Wolberger C, Matunis MJ. Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198. PLoS One. 2014 Aug 18;9(8):e105271.[PubMed]
Ringel AE, Roman C, Wolberger C. (2014) Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Protein Sci. 23(12):1686-97. [PubMed]
Yan M, Wolberger C. (2015) Uncovering the role of Sgf73 in maintaining SAGA Deubiquitinating Module Structure and Activity. J Mol Biol. 427(8):1765-78. [PubMed]
Kumar P, Wolberger C. (2015) Structure of the yeast Bre1 RING domain. Proteins 83(6):1185-90. [PubMed]
Kumar P, Magala P, Geiger-Schuller KR, Majumdar A, Tolman JR, Wolberger C. (2015) Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity. Nucleic Acids Res. 43(18):9039-50. [PubMed]
Ringel AE, Cieniewicz AM, Taverna SD, Wolberger C. (2015) Nucleosome competition reveals processive acetylation by the SAGA HAT module. Proc Natl Acad Sci U S A. 112(40):E5461-70. [PubMed]
M.T. Morgan, M. Haj-Yahya, A.E. Ringel, P. Bandi, A. Brik, C. Wolberger (2016) Structural basis for histone H2B deubiquitination by the SAGA DUB module. Science 351, 725-728. [PubMed]
Jbara M, Maity SK, Morgan M, Wolberger C, Brik A. (2016) Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module. Angew Chem Int Ed Engl. ;55(16):4972-6. [PubMed]
Bheda P, Jing H, Wolberger C, Lin H. (2016) The Substrate Specificity of Sirtuins.  Annu Rev Biochem. 85:405-29. [PubMed]
Ringel AE, Wolberger C. (2016) Structural basis for acyl-group discrimination by human Gcn5L2. Acta Crystallogr D Struct Biol. 72(Pt 7):841-8. [PubMed]
Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA. (2016) Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases. Biochemistry  55(26):3658-66. [PubMed]
DiBello A, Datta AB, Zhang X, Wolberger C. (2016) Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination. J Mol Biol. 428(23):4639-4650. [PubMed]
Morgan MT, Wolberger C. (2017) Recognition of ubiquitinated nucleosomes. Curr Opin Struct Biol. 42:75-82.  [PubMed]
Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L. (2017) Mutations that Allow SIR2 Orthologs to Function in a NAD(+)-Depleted Environment. Cell Rep.  18(10):2310-2319. [PubMed]
Bondalapati S, Eid E, Mali SM, Wolberger C, Brik A. (2017) Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags. Chem Sci. 8(5):4027-4034. [PubMed]
Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. (2017) A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell. 66(3):345-357. [PubMed]
Lombardi PM, Matunis MJ, Wolberger C. RAP80, ubiquitin and SUMO in the DNA damage response. (2017) J Mol Med 95(8):799-807. [PubMed]
Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N. (2017) A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature 551(7680):389-393. [PubMed]